花心渣男萊恩在紀念日劈腿第一千任女友，沒想到對方竟是女巫！她怒下詛咒，萊恩竟變成只對男人心動的0號，更要集滿一千個男人才能變回直男。 詛咒生效，他偏偏遇上身為同志的死對頭伊森。萊恩拼命抗拒，身體卻早已不受控，對這位宿敵產生了致命的吸引力…
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